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Skin substitutes are a heterogeneous group of biologic, synthetic, or biosynthetic materials that can provide temporary or permanent coverage of open skin wounds. The aim of skin substitutes is to replicate the properties of the normal skin. Skin substitutes are an important adjunct in the management of acute or chronic wounds and can be used to cover defects following burns or other injuries, or for reconstruction.

 

Biologic wound healing therapies are those that are intended to facilitate the re-establishment of the innate repair mechanisms, and may involve the application of active biological agents, such as plant-derived active biomolecules which exhibit antioxidant, antimicrobial, or anti-inflammatory attributes. Biologic dressings prevent evaporative water loss, heat loss, protein and electrolyte loss, and contamination. They also permit autolytic debridement and develop a granular wound bed.